Syndromes with musculoskeletal implications include those diagnoses that may result in or be associated with musculoskeletal problems or deformities. The most common syndromes with musculoskeletal implications include Marfan syndrome, Ehlers Danlos syndrome, Down syndrome, and neurofibromatosis. These patients may have musculoskeletal problems including scoliosis, pectus deformities, hip dysplasia, and flatfeet. Patients with neurofibromatosis may have congenital pseudarthrosis of the tibia. Many of these patients will require treatment for these musculoskeletal problems. Treatment, however, must be tailored to each individual patient as these syndromes often affect multiple body systems and require involvement of multiple medical disciplines.